For all study cohorts the Chronic Kidney Disease Epidemiology Collaboration creatinine equation was used for glomerular filtration rate estimation ( 8). Case subjects were categorized based on having an annual eGFR decline of ≥3 mL/min/1.73 m 2 and control subjects an annual eGFR decline of <1 mL/min/1.73 m 2 over a median 8 years (interquartile range 5–12) of follow-up. The JDRF Biomarkers Consortium performed a multinational case-control study nested within four longitudinal T1D cohorts, those of the Finnish Diabetic Nephropathy (FinnDiane) Study, the Steno Diabetes Center Copenhagen study (Steno), the Epidemiology of Diabetes Complications (EDC) study, and the Coronary Artery Calcification in Type 1 Diabetes study (CACTI) ( 7).
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